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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
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FDA-Approved Chimeric Antigen Receptor (CAR)-T Cell Therapy for Different Cancers-A Recent Perspective.

R Thirumalaisamy1, S Vasuki2, S M Sindhu2,3

  • 1Department of Biotechnology, Sona College Arts and Science, Salem (Dt.), Tamil Nadu, 636005, India. tmalaisamy@gmail.com.

Molecular Biotechnology
|March 8, 2024
PubMed
Summary

Chimeric Antigen Receptor-T (CAR-T) cell therapy offers novel treatment options for various cancers, addressing a growing global health challenge. This review explores CAR-T therapy

Keywords:
CancerChimeric Antigen Receptor-T cell (CAR-T)NovelTherapeutics

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Area of Science:

  • Oncology and Immunology
  • Biotechnology and Genetic Engineering

Background:

  • Cancer incidence is rising globally, posing a significant public health challenge.
  • Chimeric Antigen Receptor-T (CAR-T) cell therapy represents a promising novel treatment modality.
  • Low- and middle-income countries (LMICs) are disproportionately affected by cancer, aligning with UN Sustainable Development Goal 3.

Purpose of the Study:

  • To review novel Chimeric Antigen Receptor-T (CAR-T) cell therapy treatment options for various cancers.
  • To discuss the molecular mechanisms, merits, and advantages of CAR-T cell therapy in cancer treatment.
  • To provide insights into utilizing CAR-T cell protocols for patient rejuvenation and potential disease eradication.

Main Methods:

  • Comprehensive literature search of CAR-T cell therapy for various cancers.
  • Databases searched: Google Scholar, Science Direct, and PubMed.
  • Inclusion criteria: Articles published between January 2000 and December 2023; 48 eligible papers selected from 18,700.

Main Results:

  • CAR-T cell therapy demonstrates significant potential in treating diverse cancer types.
  • Detailed molecular mechanisms underlying CAR-T cell efficacy in cancer treatment were analyzed.
  • The review highlights the advantages of CAR-T cell therapy in improving patient outcomes and survival.

Conclusions:

  • CAR-T cell therapy is a rapidly advancing field with substantial promise for various malignancies.
  • Further research and application of CAR-T cell protocols can lead to improved cancer patient lifespans.
  • This therapy offers potential for disease rejuvenation and, in some cases, eradication.