Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiomics reveals fatty acid metabolism and immune remodeling in retinal artery occlusion.

iScience·2026
Same author

Single-Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Kynurenine-mediated redox regulation provides neuroprotection in central retinal artery occlusion.

Journal of translational medicine·2025
Same author

Risks of stroke and myocardial infarction after retinal artery occlusion and their time dependence: a systematic review and meta-analysis.

Journal of neurology·2025
Same author

Early-life inflammation increases aggressive behavior in adult male mice through an astrocyte-neuron signaling.

Molecular psychiatry·2025
Same author

Autocatalytic, Brain Tumor-Targeting Delivery of Bardoxolone Methyl Self-Assembled Nanoparticles for Glioblastoma Treatment.

Small science·2025

Related Experiment Video

Updated: Jul 1, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

7.6K

Plasmalogens and Octanoylcarnitine Serve as Early Warnings for Central Retinal Artery Occlusion.

Chuansen Wang1, Ying Li1, Jiaqing Feng1

  • 1Department of Ophthalmology, Renmin Hospital of Wuhan University, No. 238 Jie Fang Road, Wuhan, 430060, Hubei, China.

Molecular Neurobiology
|March 8, 2024
PubMed
Summary

Metabolomics identified key biomarkers, including specific phospholipids and octanoylcarnitine, for early detection of central retinal artery occlusion (CRAO). Combining these with clinical factors like HDL-C improved CRAO prediction accuracy.

Keywords:
Central retinal artery occlusionClinical parameterDifferential metabolitesMetabolomicsPrediction model

More Related Videos

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

1.8K
An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment
09:33

An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment

Published on: September 13, 2016

7.2K

Related Experiment Videos

Last Updated: Jul 1, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

7.6K
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

1.8K
An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment
09:33

An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment

Published on: September 13, 2016

7.2K

Area of Science:

  • Ophthalmology
  • Metabolomics
  • Biomarker Discovery

Background:

  • Central retinal artery occlusion (CRAO) is an ophthalmic emergency causing vision loss.
  • Limited treatment options highlight the need for early disease prevention strategies.
  • Metabolomics offers potential for identifying individuals at risk of CRAO.

Purpose of the Study:

  • To identify potential metabolic biomarkers for early detection of CRAO.
  • To compare the predictive efficacy of a combined model (metabolites and clinical factors) against clinical factors alone.

Main Methods:

  • Comparative metabolomics analysis of venous blood from CRAO and cataract patients.
  • Arteriovenous difference analysis of blood in CRAO patients.
  • Machine learning models (logistic regression, random forest, SVM) for clinical parameter screening.
  • Receiver operating characteristic (ROC) and decision curve analysis (DCA) for model performance evaluation.

Main Results:

  • Specific phospholipids (PC(P-18:0/22:6)), PC(P-18:0/20:4), and octanoylcarnitine were strongly correlated with CRAO.
  • HDL-C and ApoA1 demonstrated significant predictive value for CRAO.
  • The combined model achieved a superior AUROC of 0.815 compared to clinical parameters alone.
  • Decision curve analysis indicated a higher net benefit for the combined model.

Conclusions:

  • PC(P-18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)), PC(P-18:0/20:4(5Z,8Z,11Z,14Z)), and octanoylcarnitine are potent predictors of CRAO.
  • Integrating metabolomic data with clinical factors enhances CRAO prediction accuracy.
  • This study underscores the potential of metabolomics in early CRAO risk assessment and prevention.