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Primary hepatic angiosarcoma: a systematic review.
Santiago Rojas1, Carlos Eduardo Rey Chaves1, Sofía Robledo2
1Estudiante de posgrado Cirugía General.
Annals of Medicine and Surgery (2012)
|March 11, 2024
Summary
Surgical resection improves survival for hepatic angiosarcoma patients, offering a median overall survival of 17.18 months compared to 3.72 months for non-surgical treatment. Early diagnosis is crucial for this rare liver cancer.
Area of Science:
- Hepatology
- Surgical Oncology
- Rare Cancers
Background:
- Hepatic angiosarcoma is a rare liver tumor with nonspecific symptoms, often diagnosed late with poor prognosis.
- Current treatment strategies lack consensus, necessitating a review of surgical and survival outcomes.
Purpose of the Study:
- To comprehensively analyze evidence on surgical and survival outcomes for primary hepatic angiosarcoma.
- To evaluate disease-free survival (DFS) and overall survival (OS) in patients undergoing treatment.
Main Methods:
- Systematic review of Pubmed, EMBASE, and Scopus databases (2000-2023).
- Search terms included 'hepatic angiosarcoma' and 'liver resection' or 'hepatectomy'.
- Pooled analysis of individual patient data on prognosis and therapies.
Main Results:
- 15 articles with 886 patients were included; 66.2% were male, median age 57.
- Median OS was 7 months. Surgical resection yielded median OS of 17.18 months vs. 3.72 months for non-surgical management.
- Median DFS was 15.2 months.
Conclusions:
- Primary liver angiosarcoma presents surgical challenges and a poor prognosis despite treatment.
- Surgical management significantly increases OS compared to non-surgical approaches.
- Early diagnosis is critical; further research is needed for standardized protocols.
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