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Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms

Yue Shi1, Joseph Adu-Amankwaah1, Qizhong Zhao2

  • 1Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou, China.

Heliyon
|March 11, 2024
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key drivers of drug resistance in major cancers like breast, lung, and prostate. Understanding lncRNA mechanisms offers new hope for overcoming treatment challenges and improving patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer drug resistance is a major challenge in treating prevalent cancers, including breast, lung, colorectal, prostate, and gastric types.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their critical roles in cancer biology and the development of treatment resistance.

Purpose of the Study:

  • To review the significance of lncRNAs in mediating resistance to various cancer drugs.
  • To explore the diverse mechanisms by which lncRNAs contribute to drug resistance across common malignancies.

Main Methods:

  • Comprehensive literature review of studies on lncRNAs and cancer drug resistance.
  • Analysis of lncRNA regulatory roles in cancer cell biology and treatment response.

Main Results:

  • lncRNAs play a pivotal role in resistance to drugs such as platinum drugs (DDP), tamoxifen, trastuzumab, 5-fluorouracil (5-FU), paclitaxel (PTX), and Androgen Deprivation Therapy (ADT).
  • lncRNAs influence multiple cellular processes contributing to drug resistance in various cancer types.

Conclusions:

  • lncRNAs are crucial regulators of cancer drug resistance across major cancer types.
  • Elucidating lncRNA-mediated mechanisms can lead to improved, personalized cancer treatment strategies and better patient outcomes.
Keywords:
CancerCancer therapy resistanceChemoresistanceDrug resistancelncRNAs

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