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Late-Life Alcohol Exposure Does Not Exacerbate Age-Dependent Reductions in Mouse Spatial Memory and Brain TFEB
Biorxiv : the Preprint Server for Biology
|March 11, 2024
Summary
Aging significantly impairs spatial memory and autophagy more than alcohol consumption. This study investigated alcohol
Area of Science:
- Neuroscience
- Cell Biology
- Gerontology
Background:
- Alcohol consumption's impact on Alzheimer's disease (AD) risk is unclear.
- Autophagy, regulated by Transcription factor EB (TFEB), maintains cellular homeostasis and may mediate alcohol-AD links.
Conclusions:
- Aging is a more significant factor than alcohol consumption in driving spatial memory deficits and reduced autophagy flux.
- TFEB activity and autophagy are compromised with age, and alcohol's effects are less pronounced in aged individuals.
