Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

986
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
986
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

1.9K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
1.9K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K
Somatosensory, Motor, and Association Cortex01:24

Somatosensory, Motor, and Association Cortex

495
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
495
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

3.8K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
3.8K
Lobes of the Cerebrum01:22

Lobes of the Cerebrum

645
The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
645

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hippocampal communication with the anterior olfactory nucleus is necessary for context-dependent odor memory.

Behavioral neuroscience·2026
Same author

The Infralimbic, but not the Prelimbic Cortex is needed for a Complex Olfactory Memory Task.

bioRxiv : the preprint server for biology·2024
Same author

Time cells in the retrosplenial cortex.

Hippocampus·2024
Same author

The Retrosplenial Cortical Role in Delayed Spatial Alternation.

bioRxiv : the preprint server for biology·2024
Same author

A comparison of hippocampal and retrosplenial cortical spatial and contextual firing patterns.

Hippocampus·2024
Same author

Effects of social context manipulation on dorsal and ventral hippocampal neuronal responses.

Hippocampus·2023
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2025

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex
16:45

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex

Published on: March 13, 2016

11.5K

Time Cells in the Retrosplenial Cortex.

Dev Laxman Subramanian1, David M Smith1

  • 1Department of Psychology, Cornell University, Ithaca, NY 14853.

Biorxiv : the Preprint Server for Biology
|March 11, 2024
PubMed
Summary
This summary is machine-generated.

The retrosplenial cortex (RSC) exhibits time cells, crucial for temporal coding in episodic memory. These cells

Keywords:
episodic memoryretrosplenial cortextemporal codingtemporal contexttime cells

More Related Videos

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations
10:45

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

Published on: June 14, 2020

7.4K
Visualization of Cortical Modules in Flattened Mammalian Cortices
08:49

Visualization of Cortical Modules in Flattened Mammalian Cortices

Published on: January 22, 2018

12.9K

Related Experiment Videos

Last Updated: Jul 1, 2025

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex
16:45

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex

Published on: March 13, 2016

11.5K
Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations
10:45

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

Published on: June 14, 2020

7.4K
Visualization of Cortical Modules in Flattened Mammalian Cortices
08:49

Visualization of Cortical Modules in Flattened Mammalian Cortices

Published on: January 22, 2018

12.9K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience

Background:

  • The retrosplenial cortex (RSC) is integral to memory systems, connecting with the hippocampus and thalamus.
  • Episodic memory relies on temporal information encoding, a function observed in hippocampal time cells but not yet in the RSC.

Approach:

  • Investigated RSC neuronal firing patterns during intertrial delays in two tasks: a blocked alternation task and a cued T-maze task.
  • Rats performed tasks requiring memory of reward locations (blocked alternation) or simple cue following (cued T-maze).

Key Points:

  • Time cells were prevalent in the RSC during the blocked alternation task, differentiating between trial types.
  • RSC neurons also showed inhibited firing periods (off-response time fields).
  • Time cells were less prevalent and less discriminative in the cued T-maze task, indicating sensitivity to memory demands.

Conclusions:

  • Temporal coding is a significant feature of RSC neuronal activity.
  • RSC time cells are sensitive to task memory requirements, supporting their role in episodic memory.