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Updated: Jul 1, 2025
11:51
Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
30.5K
Drug delivery to the central nervous system
Elizabeth Nance1,2, Suzie H Pun3,2, Rajiv Saigal3,4,2
1Department of Chemical Engineering, University of Washington, Seattle, WA, USA.
Nature Reviews. Materials
|March 11, 2024
Summary
Developing new treatments for central nervous system (CNS) disorders is difficult due to physiological barriers. Biomaterials offer promising strategies for effective CNS drug delivery, overcoming these challenges.
Area of Science:
- Neuroscience
- Biomaterials Science
- Pharmacology
Background:
- Central nervous system (CNS) disorders are increasing globally, yet drug development faces significant hurdles.
- The blood-brain barrier and blood-cerebrospinal fluid barrier severely restrict drug access to the CNS.
- High costs and failure rates characterize current CNS drug development.
Purpose of the Study:
- To review the impact of CNS physiology on drug delivery.
- To discuss various biomaterial-based strategies for CNS drug delivery.
- To highlight challenges and opportunities in designing materials for CNS drug delivery.
Main Methods:
- Examination of CNS physiology and its influence on drug delivery.
- Discussion of biomaterial designs for systemic, direct CNS, intranasal, and peripheral administration.
- Analysis of current challenges and future prospects in CNS drug delivery materials.
Main Results:
- Biomaterials can be engineered to bypass or cross CNS barriers.
- Diverse administration routes (systemic, direct, intranasal, peripheral) are being explored with biomaterials.
- Understanding CNS physiology is crucial for optimizing drug delivery.
Conclusions:
- Biomaterials present a viable approach to overcome CNS drug delivery barriers.
- Further advancements in materials design are needed to enhance clinical impact.
- Optimized CNS drug delivery holds significant promise for treating neurological disorders.
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