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Updated: May 5, 2026

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Widespread Reactive Lymphatic and Splenic FDG Avidity After mRNA COVID Vaccination.
Clinical Nuclear Medicine
|March 11, 2024
Summary
Widespread FDG-avid lymphadenopathy and splenic uptake on PET/CT resolved spontaneously. This rare phenomenon occurred shortly after a COVID mRNA vaccine, suggesting a potential link.
Area of Science:
- Oncology
- Immunology
- Radiology
Background:
- Metastatic lung adenocarcinoma requires vigilant surveillance.
- Positron Emission Tomography/Computed Tomography (PET/CT) with Fluorodeoxyglucose (FDG) is crucial for monitoring treatment response and detecting recurrence.
- COVID-19 mRNA vaccination is associated with various immune responses.
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