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Related Experiment Video

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Multifunctional MXene-Based Platforms for Soft and Bone Tissue Regeneration and Engineering.

Siavash Iravani1, Ehsan Nazarzadeh Zare2,3, Pooyan Makvandi4,5,6

  • 1Independent Researcher, W Nazar ST, Boostan Avenue, Isfahan 81756-33551, Iran.

ACS Biomaterials Science & Engineering
|March 11, 2024
PubMed
Summary

MXenes show potential for tissue regeneration and engineering (TRE), but biocompatibility and scaffold morphology require further research. Future work will focus on surface modifications and in vivo studies for clinical translation.

Keywords:
MXene-based materialsMXenesbone tissue regenerationsoft tissue regenerationtissue engineering

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • MXenes and their composites offer significant potential for soft and bone tissue regeneration and engineering (TRE).
  • Key challenges include ensuring adequate biocompatibility and precise control over the morphology of MXene-based scaffolds.
  • Addressing these limitations is crucial for advancing MXene applications in TRE.

Purpose of the Study:

  • To critically evaluate the potential applications and contributions of MXenes and their composites in soft and bone TRE.
  • To provide a comprehensive analysis of the advantages, limitations, and future prospects of MXenes in TRE.
  • To consolidate current knowledge and highlight advancements in MXene-based TRE.

Main Methods:

  • Literature review and critical analysis of existing research on MXenes in tissue regeneration.
  • Examination of studies focusing on biocompatibility, scaffold morphology, and tissue interactions.
  • Synthesis of current findings to identify key advancements and challenges.

Main Results:

  • MXenes present promising properties for TRE but face hurdles in biocompatibility and morphology control.
  • Surface modifications and development of multifunctional constructs are identified as key strategies for enhancement.
  • The need for rigorous in vivo studies for clinical translation is emphasized.

Conclusions:

  • MXenes hold considerable promise for advancing soft and bone tissue regeneration and engineering.
  • Overcoming challenges in biocompatibility and morphology control is essential for clinical application.
  • Future research should prioritize in vivo validation and the development of advanced MXene-based constructs.