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U-shaped association between serum calcium and in-hospital mortality in patients with congestive heart failure
Kai Zhang1, Yu Han2, Tianyi Cai3
1Department of Cardiovascular Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.
ESC Heart Failure
|March 11, 2024
Summary
Serum calcium levels show a U-shaped association with in-hospital mortality in congestive heart failure (CHF) patients. Both low and high calcium levels increase mortality risk, with the lowest risk observed at 8.35 mg/dL.
Area of Science:
- Cardiology
- Clinical Biochemistry
Background:
- Serum calcium is a common biomarker for disease severity.
- Its precise impact on clinical outcomes in congestive heart failure (CHF) patients is not well understood.
Purpose of the Study:
- To investigate the relationship between serum calcium levels and in-hospital mortality in CHF patients.
Main Methods:
- Retrospective analysis of 15,983 CHF patients from the MIMIC database.
- Stratification of patients by serum calcium levels (quintiles).
- Statistical analysis including multivariable logistic regression, generalized additive models, and two-piecewise linear regression.
Main Results:
- A U-shaped relationship was observed between serum calcium levels and in-hospital mortality.
- Both the lowest (Q1) and highest (Q5) calcium levels were associated with increased mortality risk (OR 1.38 and 1.23, respectively).
- The lowest risk of mortality occurred at a serum calcium threshold of 8.35 mg/dL.
Conclusions:
- Serum calcium levels exhibit a U-shaped association with in-hospital mortality in CHF patients, with an inflection point at 8.35 mg/dL.
- Further prospective studies are needed to confirm these findings.
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