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Amnion-derived hydrogels as a versatile platform for regenerative therapy: from lab to market
Golara Kafili1, Hassan Niknejad2, Elnaz Tamjid3
1Center for Nanoscience and Nanotechnology, Institute for Convergence Science and Technology, Sharif University of Technology, Tehran, Iran.
Frontiers in Bioengineering and Biotechnology
|March 12, 2024
Summary
Decellularized amnion (dAM) processed into hydrogels offers versatile applications in tissue regeneration, overcoming limitations of traditional amnion sheets for minimally invasive therapies and biomaterial fabrication.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- The amnion (AM) is a promising, cost-effective tissue source for regenerative medicine due to its biological properties like low immunogenicity and anti-inflammatory effects.
- Clinical use of AM sheets is limited by handling difficulties and the need for sutures, necessitating improved processing methods.
- Decellularized AM (dAM) can be transformed into temperature-sensitive hydrogels, enhancing its utility for minimally invasive treatments and biofabrication.
Purpose of the Study:
- To review the multi-functional applications of decellularized amnion (dAM) hydrogels in various biomedical fields.
- To highlight recent advancements and commercial products derived from dAM hydrogels.
- To identify future research directions for optimizing dAM hydrogels in nanomedicine and healthcare.
Main Methods:
- Review of current literature on decellularized amnion (dAM) hydrogel applications.
- Analysis of recent research and commercially available dAM-derived products.
- Exploration of innovative techniques such as additive manufacturing, nanotechnology, and biochemical modifications.
Main Results:
- dAM hydrogels demonstrate broad applicability in skin repair, cardiac treatment, cartilage, endometrium, and dental pulp regeneration.
- Injectable dAM hydrogels serve as effective carriers and bioinks for creating biomimetic constructs.
- Commercial products showcase the therapeutic potential of AM-derived hydrogels, though further optimization is needed.
Conclusions:
- Decellularized amnion (dAM) hydrogels represent a significant advancement in regenerative medicine, offering versatile solutions for tissue repair.
- Further interdisciplinary research is crucial to enhance the mechanical and biological properties of dAM hydrogels.
- Integrating additive manufacturing, nanotechnology, and biochemical modifications will expand the therapeutic benefits and applications of dAM hydrogels.
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