Related Experiment Video
Updated: Jul 1, 2025
Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
Published on: May 27, 2022
A male fetus with cyclopia was discovered after miscarriage: A rare case report from Syria
Tala Dakkak1, Marah Mansour2,3, Habib Jarbouh4,5
1Faculty of Medicine Hama University Hama Syrian Arab Republic.
Insights
Prenatal check-ups are crucial for detecting alobar holoprosencephaly, a severe condition associated with cyclopia. Early diagnosis via ultrasound enables timely intervention, preventing significant parental psychological distress, especially in low-income settings.
Area of Science:
- Medical Genetics
- Prenatal Diagnosis
- Developmental Biology
Background:
- Alobar holoprosencephaly is a severe congenital brain malformation.
- Cyclopia represents the most extreme cranial manifestation of holoprosencephaly.
- This condition has a poor prognosis and significant implications for fetal development.
Observation:
- A case of alobar holoprosencephaly with cyclopia was identified.
- Prenatal ultrasound was instrumental in diagnosing the condition.
- The diagnosis occurred in a setting with limited resources, highlighting accessibility challenges.
Findings:
- Early and accurate prenatal diagnosis of alobar holoprosencephaly is feasible.
- Ultrasound is a key tool for identifying severe fetal anomalies like cyclopia.
- Timely diagnosis facilitates informed decision-making regarding pregnancy management.
Implications:
- Prenatal screening programs are vital, particularly in low-income countries.
- Early detection can prevent profound psychological trauma for parents.
- Facilitating early gestational termination can mitigate long-term parental mental health burden.
Key Clinical Message:
This case of alobar holoprosencephaly and cyclopia emphasizes the value of prenatal check-ups, particularly in low-income countries. Early ultrasound diagnosis leads to early gestational termination, preventing psychological trauma for the parents.
Abstract:
Alobar holoprosencephaly is a rare-occurrence malformation with a bad prognosis linked to cyclopia, the most severe cranial feature. Prenatal examinations are essential for identifying these deformities and preventing parental mental health damage.
