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Related Concept Videos

Mutations01:35

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
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Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
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SARS-CoV-2 Ultraviolet Radiation Dose-Response Behavior.

Ernest R Blatchley Iii1,2, Brian Petri3, Wenjun Sun4

  • 1Lyles School of Civil Engineering, Purdue University, West Lafayette, IN 47907, USA.

Journal of Research of the National Institute of Standards and Technology
|March 12, 2024
PubMed
Summary
This summary is machine-generated.

Ultraviolet-C (UV-C) irradiation effectively inactivates SARS-CoV-2, the virus causing COVID-19, similar to its effect on SARS-CoV. Further research is needed to optimize UV-C disinfection for various conditions.

Keywords:
COVID-19SARS-CoV-2disinfectionultraviolet radiationvirus

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Area of Science:

  • Microbiology
  • Virology
  • Public Health

Background:

  • Ultraviolet (UV) radiation, particularly UV-C (200–320 nm), is a known germicide effective against various pathogens.
  • Previous studies confirmed UV-C efficacy against SARS-CoV, the virus responsible for the 2003 SARS outbreak.
  • SARS-CoV-2, the virus causing COVID-19, shares structural similarities with SARS-CoV.

Purpose of the Study:

  • To evaluate the anticipated effectiveness of UV radiation for SARS-CoV-2 inactivation.
  • To review existing data and models predicting UV inactivation of SARS-CoV-2.
  • To identify knowledge gaps and areas for future research in UV-C disinfection of coronaviruses.

Main Methods:

  • Review of recently published data on UV inactivation of SARS-CoV-2.
  • Analysis of predictive models based on viral genomic and other characteristics for UV inactivation at 254 nm.
  • Comparison of model predictions with experimental viral inactivation measurements.

Main Results:

  • Published data support UV radiation's effectiveness against SARS-CoV-2 under specific conditions.
  • Predictive models based on viral characteristics align with experimental inactivation data for SARS-CoV-2.
  • UV-C irradiation is indicated as a viable method for controlling SARS-CoV-2 and other coronaviruses.

Conclusions:

  • UV-C irradiation is expected to be effective for controlling SARS-CoV-2.
  • Current evidence supports the use of UV-C for disinfection against SARS-CoV-2.
  • Further research is required to determine optimal UV-C disinfection parameters, including wavelength, humidity effects, and medium of exposure.