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The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Updated: Jul 1, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

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Published on: February 27, 2019

AagingBase: a comprehensive database of anti-aging peptides.

Kunjulakshmi R^1,2, Ambuj Kumar¹, Keerthana Vinod Kumar¹

¹Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Telangana 502284, India.

Database : the Journal of Biological Databases and Curation

|March 12, 2024

Summary

AagingBase is a new database featuring 282 validated anti-aging peptides. It aids researchers in identifying and prioritizing peptide therapeutics for aging by providing physicochemical properties and advanced search tools.

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Area of Science:

Biotechnology
Geriatric Medicine
Computational Biology

Background:

Aging is an inevitable biological process impacting all organisms.
Peptide therapeutics offer promising anti-aging interventions due to low immunogenicity and cost-effective production.
Understanding peptide physicochemical properties is crucial for developing effective anti-aging treatments.

Purpose of the Study:

To create a comprehensive database, AagingBase, for anti-aging peptides.
To facilitate research on aging and peptide therapies.
To provide researchers with essential data for identifying potential anti-aging peptide candidates.

Main Methods:

Compiled 282 experimentally validated anti-aging peptides from research articles and patents.
Performed rigorous physicochemical calculations using computational techniques.
Integrated advanced search, filtering, and similarity search functionalities.

Main Results:

AagingBase contains 282 validated anti-aging peptides with detailed physicochemical analyses.
The database includes information on atomic and amino acid compositions, secondary and tertiary structures.
Users can perform advanced searches to understand peptide functions and biological roles.

Conclusions:

AagingBase serves as a valuable resource for advancing geriatric medicine research.
The database enables efficient identification and prioritization of anti-aging peptide therapeutics.
AagingBase is freely accessible, promoting innovation in peptide-based anti-aging strategies.