Related Experiment Video
Updated: Jun 20, 2026
07:23
Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
7.6K
Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA.
Gavrielle R Untracht1,2, Madeleine S Durkee3, Mei Zhao4
1Department of Health Technology, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Scientific Reports
|March 13, 2024
Summary
A new open-source tool, OCTAVA, provides reliable retinal microvascular analysis from various optical coherence tomography angiography (OCTA) instruments. This enhances the reproducibility of quantitative imaging for disease biomarker discovery.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Quantitative assessment of retinal microvasculature in optical coherence tomography angiography (OCTA) is crucial for disease diagnosis and monitoring.
- Current OCTA analysis tools lack universality and transparency, leading to inconsistent microvascular metrics across different instruments and datasets.
Purpose of the Study:
- To introduce a retinal extension to the OCTA Vascular Analyser (OCTAVA) for robust, user-friendly, and transparent analysis of retinal OCTA images.
- To address the need for standardized and reproducible quantitative analysis of retinal microvasculature.
Main Methods:
- Development of OCTAVA, an open-source toolbox for analyzing retinal OCTA images from various instruments.
- Validation of OCTAVA using datasets from four commercial OCTA instruments across different sites and study cohorts.
- Calculation of seven microvascular metrics and six foveal avascular zone metrics.
Main Results:
- OCTAVA demonstrated robust performance across diverse OCTA datasets, showing consistent results regardless of the instrument or acquisition site.
- The toolbox provided retinal microvascular metric values comparable to existing literature.
- OCTAVA reduced the variation in metric values between studies compared to commercial analysis tools.
Conclusions:
- OCTAVA offers a standardized, transparent, and user-friendly solution for quantitative analysis of retinal OCTA images.
- The public availability of OCTAVA aims to improve research reproducibility and facilitate the identification of reliable biomarkers for ocular and systemic diseases.
