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¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...

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Related Experiment Video

Updated: Jul 1, 2025

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Correction: Complex peptide macrocycle optimization: combining NMR restraints with conformational analysis to guide

Ajay N Jain¹, Alexander C Brueckner², Christine Jorge²

¹Research and Development, BioPharmics LLC, Sonoma County, CA, USA. ajain@jainlab.org.

Journal of Computer-Aided Molecular Design

|March 13, 2024

Summary

No abstract available in PubMed .

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