Comparative Study of Eclipse and RayStation Multi-Criteria Optimization-Based Prostate Radiotherapy Treatment...

Multi-criteria optimization (MCO) function has been available on commercial radiotherapy (RT) treatment planning systems to improve plan quality; however, no study has compared Eclipse and RayStation MCO functions for prostate RT planning. The purpose of this study was to compare prostate RT MCO plan qualities in terms of discrepancies between Pareto optimal and final deliverable plans, and dosimetric impact of final deliverable plans. In total, 25 computed tomography datasets of prostate cancer patients were used for Eclipse (version 16.1) and RayStation (version 12A) MCO-based plannings with doses received by 98% of planning target volume having 76 Gy prescription (PTV₇₆D_98%) and 50% of rectum (rectum D_50%) selected as trade-off criteria. Pareto optimal and final deliverable plan discrepancies were determined based on PTV₇₆D_98% and rectum D_50% percentage differences. Their final deliverable plans were compared in terms of doses received by PTV₇₆ and other structures including rectum, and PTV₇₆ homogeneity index (HI) and conformity index (CI), using a t-test. Both systems showed discrepancies between Pareto optimal and final deliverable plans (Eclipse: -0.89% (PTV₇₆D_98%) and -2.49% (Rectum D_50%); RayStation: 3.56% (PTV₇₆D_98%) and -1.96% (Rectum D_50%)). Statistically significantly different average values of PTV₇₆D_98%,HI and CI, and mean dose received by rectum (Eclipse: 76.07 Gy, 0.06, 1.05 and 39.36 Gy; RayStation: 70.43 Gy, 0.11, 0.87 and 51.65 Gy) are noted, respectively (p < 0.001). Eclipse MCO-based prostate RT plan quality appears better than that of RayStation.