T Cell Immunity in Human Papillomavirus-Related Cutaneous Squamous Cell Carcinoma-A Systematic Review
Shi Huan Tay1, Choon Chiat Oh1,2
1Duke-NUS Medical School, Singapore 169857, Singapore.
Diagnostics (Basel, Switzerland)
|March 13, 2024
Summary
T cell immunity loss, particularly with beta human papillomavirus (β-HPV) infection, promotes skin cancer (cSCC) development. This suggests T-cell focused therapies could prevent cSCC in high-risk individuals.
Area of Science:
- Oncology
- Immunology
- Dermatology
Background:
- Cutaneous squamous cell carcinoma (cSCC) is a significant skin cancer, especially in immunosuppressed individuals.
- Associations between cSCC, immunosuppression, and human papillomavirus (HPV) suggest a complex interplay in cancer development.
Purpose of the Study:
- To investigate the role of T cell immunity in the context of HPV infection and cSCC development.
- To explore the mechanisms linking immunosuppression, HPV, and skin carcinogenesis.
Main Methods:
- Literature review focusing on T cell immunity in HPV-related cSCC.
- Analysis of existing data on the interplay between immunosuppression, HPV, and environmental factors.
Main Results:
- Loss of T cell immunity, combined with beta-HPV (β-HPV) infection, facilitates cSCC initiation.
- Environmental carcinogens or chronic trauma can trigger cSCC in this susceptible context.
Conclusions:
- T cell immunity plays a critical role in preventing HPV-related cSCC.
- Targeting T cell immunity offers potential therapeutic and preventive strategies for at-risk populations.
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