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Updated: Jul 1, 2025

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Current Trends in Sirtuin Activator and Inhibitor Development.

Karina L Bursch1,2, Christopher J Goetz1, Brian C Smith1,2,3

  • 1Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Molecules (Basel, Switzerland)
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Summary
This summary is machine-generated.

Sirtuins, crucial metabolic regulators, can be protective or detrimental. This review highlights key activators and inhibitors for sirtuin research and therapeutic development.

Keywords:
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Area of Science:

  • Biochemistry and Molecular Biology
  • Metabolism and Aging Research

Background:

  • Sirtuins (NAD+-dependent deacetylases) are vital metabolic regulators influencing cellular processes.
  • Human sirtuins (Sirt1-7) have varied roles, linked to both lifespan extension and aging-related diseases.

Purpose of the Study:

  • To review well-characterized sirtuin activators and inhibitors.
  • To guide researchers in selecting potent and selective modulators for studying sirtuin roles in health and disease.

Main Methods:

  • Literature review of existing sirtuin activators and inhibitors.
  • Focus on compounds with demonstrated selectivity, potency, and cellular activity.

Main Results:

  • Identification of key sirtuin activators and inhibitors with therapeutic potential.
  • Discussion of the dual roles of sirtuins in cellular functions.

Conclusions:

  • Sirtuin modulators are promising for understanding sirtuin biology and developing novel therapeutics.
  • Recommendations are provided for selecting optimal sirtuin modulators for research.