Menopause Hot Flashes and Molecular Mechanisms Modulated by Food-Derived Nutrients

Area of Science:

• Reproductive biology and molecular nutrition.
• Investigates the molecular underpinnings of menopausal vasomotor symptoms.

Background:

• The precise causes of hot flashes, a common menopausal symptom, remain unclear but involve complex molecular and genetic factors.
• Dietary nutrients and bioactive compounds interact with cellular metabolism and signaling pathways relevant to these symptoms.

Purpose of the Study:

• To review recent literature (last 5 years) on molecular factors and signaling pathways implicated in menopausal hot flashes.
• To identify potential natural therapeutic agents from food sources that may alleviate these symptoms.

Main Methods:

• Literature review focusing on genome-wide association studies (GWAS) and molecular pathways.
• Analysis of experimental data on food compounds affecting identified pathways.

Main Results:

• Key pathways identified include kisspeptin-GnRH, adipocyte hormones, aryl hydrocarbon receptor, estrogen metabolism, inflammation, oxidative stress, and glucose availability.
• Specific food compounds and ingredients show potential to modulate these pathways.

Conclusions:

• Understanding the molecular basis of hot flashes can guide the identification of natural interventions.
• Dietary strategies targeting specific molecular pathways may offer effective relief for menopausal vasomotor symptoms.