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Inter-scanner Aβ-PET harmonization using barrel phantom spatial resolution matching.

Gihan P Ruwanpathirana1,2, Robert C Williams2, Colin L Masters3,4

  • 1Department of Biomedical Engineering The University of Melbourne Melbourne VIC Australia.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
|March 13, 2024
PubMed
Summary
This summary is machine-generated.

Matching spatial resolution between PET scanners using a barrel phantom harmonizes amyloid beta-positron emission tomography (Aβ-PET) measurements. This method ensures consistent Aβ-SUVR quantitation across different scanners, crucial for multi-center trials.

Keywords:
PET scanner harmonizationPhilips TF64SIEMENS VisionSIEMENS mCTamyloid beta

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Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Radiochemistry

Background:

  • Standardized uptake value ratio (SUVR) measures amyloid beta-positron emission tomography (Aβ-PET) uptake in the brain.
  • Variability in PET scanner technology and reconstruction techniques causes inconsistencies in Aβ-PET images.
  • Harmonization is essential for consistent Aβ-PET measurements across multiple centers and scanners.

Purpose of the Study:

  • To propose and validate an Aβ-PET harmonization method based on matching spatial resolution.
  • To assess the consistency of Aβ-PET measurements across different PET scanners using phantom-derived spatial resolution.
  • To improve the reliability of Aβ-PET quantitation in multi-center clinical trials.

Main Methods:

  • Evaluated three PET scanners: Siemens Biograph Vision 600, Siemens Biograph mCT, and Philips Gemini TF64.
  • Calculated the full-width at half-maximum (FWHM) using [18F]-filled barrel phantom scans for each scanner's reconstruction configuration.
  • Assessed statistical similarity between regional SUVRs using paired t-tests on data from subjects scanned on multiple scanners.

Main Results:

  • Specific FWHM values were identified for each scanner pair that maximized statistical similarity in regional SUVRs (e.g., Vision 4.10 mm vs. mCT 4.30 mm).
  • Matched barrel phantom spatial resolutions (FWHM) between scanner pairs led to maximal harmonization of Aβ-PET quantitation.
  • The method demonstrated effectiveness in harmonizing SUVRs across different scanner types and reconstruction settings.

Conclusions:

  • Matching spatial resolution derived from barrel phantom scans effectively harmonizes Aβ-PET quantitation between PET scanner pairs.
  • This harmonization technique enhances the consistency and validity of Aβ-PET measurements in multi-center studies.
  • The proposed method offers a practical approach for ensuring reliable Aβ-PET data across different imaging sites and over time.