Related Experiment Video
Updated: Jul 1, 2025
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.5K
A Comprehensive Retrospective Institutional Study for Decoding Oral Squamous Cell Carcinoma
Prathiba Reichal1, Roland Prethipa1
1Oral Medicine and Radiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha University, Chennai, IND.
Cureus
|March 13, 2024
Summary
Oral squamous cell carcinoma (OSCC) predominantly affects males in their fifth to seventh decades, with advanced T4a staging common in long-term oral habit users. Early screening and antitobacco programs are crucial for prevention and improving quality of life.
Area of Science:
- Oncology
- Dental Medicine
- Public Health
Background:
- Oral cancer, including oral squamous cell carcinoma (OSCC), is a significant global health concern, ranked thirteenth most common cancer by the WHO.
- OSCC is strongly linked to detrimental oral habits like smoking, tobacco chewing, betel quid use, and alcohol consumption.
Purpose of the Study:
- To analyze demographic and clinicopathological factors associated with oral squamous cell carcinoma (OSCC).
- To investigate the correlation between habit duration, tumor staging, and the presence of perineural invasion (PNI) and lymphovascular invasion (LVI).
Main Methods:
- A three-year retrospective analysis of patient records from March 2020 to September 2023 was conducted.
- Demographic data (age, gender, habit duration) and clinicopathological data (site, TNM staging, PNI, LVI, quality of life) were retrieved.
- Statistical analysis was performed using IBM SPSS Statistics.
Main Results:
- OSCC predominantly affected males (78.35%) aged 50-70 years, with the buccal mucosa being the most common site (33.3%).
- A majority of patients presented with T4a staging (40.54%), associated with habit durations exceeding five years.
- Perineural invasion (PNI) and lymphovascular invasion (LVI) were observed in 22.52% and 0.9% of cases, respectively, with a statistically significant correlation (p < 0.05).
Conclusions:
- Advanced T4a tumor staging and prolonged habit duration (>5 years) are prevalent in OSCC cases.
- Perineural and lymphovascular invasion significantly impact nodal metastasis, treatment, recurrence, and oral health-related quality of life.
- Comprehensive antitobacco strategies, public awareness programs, and early screening are vital for OSCC prevention and improved patient outcomes.
