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Updated: Jul 1, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis, characterization and in vitro antiproliferative effects of isosteviol derivatives
Xin-Xin Qi1, Pan-Pan Wang1, Lan-Tian Cui2
1School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
Abstract:
Nineteen isosteviol derivatives were designed and synthesized by C-16, C-19 and D-ring modifications of isosteviol. These compounds were screened for their cytotoxic activities against Hela and A549 cells in vitro. Among them, the inhibitory effect of compounds 3b and 16 on Hela cells was comparable to that of the positive control gefitinib, and the compounds 3b (IC50=7.84 ± 0.84 μM) and 7a (IC50=6.89 ± 0.33 μM) exhibited significant cytotoxicity superior to gefitinib (IC50=11.02 ± 3.27 μM) against A549 cells.
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