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Updated: Jul 1, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Light-Driven Three-Component Carbonylation of Aryl Halides Using Abundant Metal Carbonyl
Quansheng Mou1, Tongyu Han1, Mingxin Liu1
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Abstract:
Carbonyl compounds are widely found in various pharmaceutical intermediates and synthetic precursors. Herein we report a simple light-driven three-component aryl halide process for synthesizing a variety of carbonylation products, utilizing Co2(CO)8 as an abundant solid carbonyl source, in good to excellent yields. The products can easily be subjected to further functionalization in synthesis. Mechanism studies indicated that this reaction is enabled by aryl radical generation and the subsequent CO insertion, alkene insertion, and protonation process.
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