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Updated: Jul 1, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
11.4K
[Periodontitis - an often neglected risk factor for several other diseases]
Anders Gustafsson1, Anna Norhammar2, Björn Klinge3
1professor, övertandläkare, Karolinska institutet, Stockholm, Karolinska institutet, Stockholm.
Lakartidningen
|March 13, 2024
Summary
Periodontitis is a chronic inflammatory disease affecting 19% globally, causing tooth loss and bone degradation. This condition is strongly linked to diabetes, cardiovascular disease, and cancer.
Area of Science:
- Periodontology
- Chronic inflammatory diseases
- Oral health research
Context:
- Periodontitis affects 19% globally and 11% in Sweden, typically manifesting between ages 35-45.
- It involves inflammation degrading dental supporting tissues, including alveolar bone.
- The disease is linked to systemic conditions like diabetes, cardiovascular disease, and cancer.
Purpose:
- To summarize the key aspects of periodontitis.
- To highlight its prevalence, pathogenesis, and systemic associations.
- To underscore the importance of understanding its bidirectional relationship with other diseases.
Summary:
- Periodontitis is a chronic inflammatory condition leading to the destruction of dental supporting tissues and alveolar bone.
- Its pathogenesis involves an aberrant inflammatory response to bacteria in the gingival crevice.
- The disease has a significant global prevalence and is bidirectionally linked with diabetes, increasing risks for cardiovascular disease and cancer.
Impact:
- Increased awareness of periodontitis as a significant public health issue.
- Highlights the crucial link between oral health and systemic diseases.
- Emphasizes the need for further research into the bidirectional relationship between periodontitis and conditions like diabetes.
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