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Updated: Jul 1, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance
Reza Dabbaghipour1, Elham Ahmadi2, Mona Entezam3
1Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran AND Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. dabaghipourreza@gmail.com.
Abstract:
Scientific research over the past decades has proven the pivotal role of long non-coding RNAs (LncRNAs) in regulating gene expression. The immune responses are controlled through the interaction of pro-inflammatory (predominance of T helper 17 cells (Th17)) and anti-inflammatory cytokines excretion (predominance of Regulatory T cells (Treg)). Recent studies have marked the impact of many diverse LncRNAs on Treg/Th17 imbalances. Moreover, some of the roots and causes of human diseases can be associated with the alterations in the Th17/Treg ratio. In this review study, we overviewed the association between LncRNAs and Th17/Treg, with the potential of providing novel prognostic and diagnostic biomarkers and promising therapeutic targets in various diseases, particularly cancer.
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