Related Experiment Video
Updated: Jul 1, 2025
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
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Risk Factors for Microscopic Disease Positivity at Ileocolic Resection Margins for Crohn's Disease
Adam Truong1, Jino Chough1, Karen N Zaghiyan1
1Department of Colon and Rectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California.
Surgical Technology International
|March 13, 2024
Summary
Repeat ileocolic resection and granuloma presence predict microscopic margin positivity in Crohn's disease patients. This finding is crucial for understanding disease recurrence after surgery.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Microscopic margin positivity in Crohn's disease surgery is linked to recurrence.
- Understanding risk factors for positive margins is essential for improving patient outcomes.
Purpose of the Study:
- To identify risk factors for microscopic margin positivity after ileocolic resection (ICR) in Crohn's disease.
Main Methods:
- A prospectively maintained database of Crohn's disease patients undergoing ICR was queried.
- Margin positivity was defined by specific histological features at proximal or distal margins.
- Multivariable logistic regression analysis was used to identify predictors.
Main Results:
- 17% of 584 patients had positive microscopic margins.
- Repeat ileocolic resection was associated with lower odds of positive margins (OR 0.46).
- Granuloma presence was associated with increased odds of positive margins (OR 2.26).
Conclusions:
- Repeat ileocolic resection and granuloma presence are significant predictors of microscopic margin disease.
- These findings can inform surgical strategies and patient management to reduce recurrence.
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