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Surgical incision pain induced an increase in alcohol consumption in mice.

Sofia Ghani1, Yasmin Alkhlaif1, Jared Mann1

  • 1Department of Pharmacology and Toxicology, Virginia Commonwealth University, USA.

Alcohol (Fayetteville, N.Y.)
|March 13, 2024
PubMed
Summary
This summary is machine-generated.

Postoperative pain in male mice increases alcohol intake and preference. Pain relief medication blocked this effect, suggesting sex and pain sensitivity influence the alcohol-pain relationship.

Keywords:
acute painalcohollaparotomymice

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Population studies indicate a link between alcohol consumption and pain perception.
  • Increased pain intensity correlates with higher alcohol intake and hazardous drinking, raising the risk for alcohol use disorders (AUD).

Purpose of the Study:

  • To investigate the impact of acute postoperative pain on alcohol consumption using animal models.
  • To characterize alcohol intake and preference in mice following surgical procedures.

Main Methods:

  • Utilized a 2-bottle choice paradigm to assess alcohol intake and preference in mice after laparotomy.
  • Administered ketoprofen to evaluate its effect on alcohol consumption post-surgery.
  • Assessed alcohol initial sensitivity and acute functional tolerance via loss of righting reflex (LORR).

Main Results:

  • Laparotomy surgery significantly increased alcohol intake and preference in male mice, but not in females.
  • Ketoprofen administration prevented the surgery-induced increase in alcohol consumption in males.
  • Post-surgical changes in alcohol initial sensitivity and acute functional tolerance were observed in mice.

Conclusions:

  • Sex differences play a role in the relationship between pain and alcohol consumption.
  • Pain and alcohol sensitivity factors may modulate the interaction between alcohol use and pain.