Association of Depression With Myocardial Infarction With Non-obstructive Coronary Arteries: A Systematic Review

Area of Science:

• Cardiology
• Psychiatry
• Systematic Review

Background:

• Myocardial infarction with non-obstructive coronary arteries (MINOCA) presents unique challenges in diagnosis and management.
• The role of psychological factors, particularly depression, in MINOCA is not fully understood.

Purpose of the Study:

• To systematically review the existing literature on the association between depression and MINOCA.
• To evaluate depression as a potential risk factor and prognostic indicator in MINOCA.

Main Methods:

• A comprehensive literature search was performed across multiple electronic databases.
• Six small case-control and cohort studies from diverse geographical locations were included.
• Study designs encompassed cohort, case-control, and prospective cohort studies.

Main Results:

• A significant association was found between depression and MINOCA.
• MINOCA patients exhibited a higher prevalence of depression compared to those with obstructive coronary artery disease.
• Depression correlated with adverse outcomes, including increased cardiovascular events, mortality, and reduced quality of life.

Conclusions:

• Depression is a significant factor associated with MINOCA, impacting patient prognosis.
• Identifying and managing depression in MINOCA patients is crucial for improving clinical outcomes.
• Further research, including multi-center randomized controlled trials, is warranted to elucidate mechanisms and develop interventions.