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Deep brain stimulation does not modulate resting-state functional connectivity in essential tremor.

Amar Awad1,2, Filip Grill1,3, Patric Blomstedt4

  • 1Umeå Center for Functional Brain Imaging (UFBI), Umeå University, 90187 Umeå, Sweden.

Brain Communications
|March 14, 2024
PubMed
Summary

Deep brain stimulation for essential tremor does not alter resting-state brain connectivity. This suggests that the treatment

Keywords:
caudal zona incertadeep brain stimulationessential tremorfunctional connectivityresting-state fMRI

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Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Essential tremor (ET) is a neurological condition characterized by action-induced tremor.
  • The precise mechanisms underlying deep brain stimulation (DBS) efficacy in ET remain elusive.
  • A dysfunction in the cerebello-thalamo-cerebral circuit is hypothesized to drive ET symptoms.

Purpose of the Study:

  • To investigate the impact of DBS on resting-state functional connectivity in ET patients.
  • To determine if DBS modulates neural network activity during rest.
  • To explore the relationship between DBS effects and the cerebello-thalamo-cerebral circuit.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed in 16 ET patients with implanted DBS.
  • Resting-state functional connectivity was assessed during both 'On' and 'Off' therapeutic DBS stimulation.
  • Seed-based and data-driven approaches were used to analyze connectivity patterns in sensorimotor and non-sensorimotor regions.

Main Results:

  • Deep brain stimulation did not significantly modulate resting-state functional connectivity in essential tremor patients.
  • No differences in functional connectivity were observed between 'On' and 'Off' DBS conditions.
  • This finding contrasts with previously observed DBS effects during motor tasks.

Conclusions:

  • The lack of effect on resting-state connectivity suggests that DBS modulation in ET may be action-dependent.
  • DBS efficacy in essential tremor might rely on altering task-related network activity rather than baseline connectivity.
  • Further research is needed to elucidate the precise action-dependent mechanisms of DBS in essential tremor.