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Related Concept Videos

Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

759
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
759
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

414
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
414
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

624
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
624
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

430
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
430
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

410
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
410
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

442
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
442

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Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
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Local Anesthetic Systemic Toxicity: Ensuring Sustained Nursing Knowledge in a High-Volume Outpatient Surgery Center.

Alicia White1, Cia Rougeau1, Tabatha Gilbert1

  • 1Outpatient Surgery Center, UVA Health, Charlottesville, VA.

Journal of Perianesthesia Nursing : Official Journal of the American Society of Perianesthesia Nurses
|March 14, 2024
PubMed
Summary

Standardizing care for local anesthetic systemic toxicity (LAST) is crucial. Simulation combined with education and system changes significantly improved nurses' knowledge and confidence in managing LAST events.

Keywords:
LASTambulatory surgerylocal anesthetic systemic toxicitynursing educationoutpatient surgery centersimulation

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Area of Science:

  • Anesthesiology
  • Nursing Education
  • Patient Safety

Background:

  • Local anesthetic systemic toxicity (LAST) is a rare but severe complication of anesthetic procedures.
  • Effective management of LAST requires prompt recognition and skilled intervention.
  • Existing knowledge gaps among nurses can hinder timely and appropriate LAST care.

Purpose of the Study:

  • To standardize the management of local anesthetic systemic toxicity (LAST) within an academic medical center.
  • To enhance and sustain nurses' knowledge and competence in recognizing and managing LAST scenarios.
  • To improve patient safety by ensuring consistent and evidence-based LAST care.

Main Methods:

  • A quantitative design was employed, utilizing an interdisciplinary team approach.
  • A clinical practice guideline based on the LAST Checklist was developed.
  • Multimodal education, simulation, and system changes were implemented to ensure sustained knowledge and competency.

Main Results:

  • Nurses' knowledge assessment scores significantly improved post-intervention (from 4.76 to 6.34 out of 7).
  • These improvements were sustained at 9 months post-intervention (score = 6.19).
  • Nurses reported increased confidence and requested regular simulation sessions.

Conclusions:

  • Standardizing LAST care using evidence-based guidelines is essential for patient safety.
  • Simulation, multimodal education, and system changes are effective strategies for ensuring sustained nursing knowledge in managing LAST.
  • Regular simulation and integrated learning modules can maintain high competency levels.