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Laboratory Testing for Endocrine Hypertension: Current and Future Perspectives

Louisiane Courcelles1, Maria Stoenoiu2, Vincent Haufroid1,3

  • 1Department of Laboratory Medicine, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium.

Clinical Chemistry
|March 14, 2024
PubMed

Insights

Secondary hypertension (SH) is high blood pressure from an underlying condition. Early detection and treatment of endocrine causes are crucial for managing cardiovascular risk and potential cures.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Biomarker Discovery

Background:

  • Secondary hypertension (SH) arises from identifiable underlying conditions, posing significant cardiovascular risk.
  • While less common than primary hypertension, SH requires prompt diagnosis and management due to potential curability.
  • Endocrine disorders are a key focus in secondary hypertension etiology.

Purpose of the Study:

  • To review endocrine causes of secondary hypertension.
  • To discuss current diagnostic biomarkers, methods, and strategies.
  • To explore the role of emerging -omics technologies in SH assessment.

Main Methods:

  • Review of current literature on endocrine causes of SH.
  • Analysis of established and emerging biomarkers and analytical techniques.
  • Evaluation of diagnostic strategies for SH phenotypes.

Main Results:

  • Endocrine SH is complex, necessitating thorough screening and confirmatory testing.
  • Biomarker interpretation requires careful consideration of interferences and variability.
  • Liquid chromatography-tandem mass spectrometry offers superior sensitivity for low-concentration hormone measurement.

Conclusions:

  • Proper screening and testing are vital to prevent diagnostic delays in endocrine SH.
  • Expertise is required for advanced analytical methods like LC-MS/MS.
  • -Omics technologies hold promise for identifying novel SH biomarkers and therapeutic targets.
Abstract

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