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Disorders of the Urinary System01:20

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The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Updated: Jun 30, 2025

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
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Characteristics Associated With Recurrent Urinary Tract Infections: A Case-Control Study.

Hannah L Chapman1, Joseph T Edwards, Alfonsus Adrian Hadikusumo Harsono

  • 1From the Department of Obstetrics and Gynecology; University of Alabama at Birmingham, Birmingham, AL.

Urogynecology (Philadelphia, Pa.)
|March 14, 2024
PubMed
Summary

Recurrent urinary tract infections (rUTIs) in women are linked to pelvic floor disorders. Prolapse may reduce rUTI risk, while parity, comorbidities, and urinary retention increase it.

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Area of Science:

  • Urogynecology
  • Epidemiology
  • Clinical Medicine

Background:

  • Recurrent urinary tract infections (rUTIs) significantly impact women's quality of life.
  • Understanding risk factors is crucial for developing effective prevention strategies.

Purpose of the Study:

  • To identify clinical characteristics associated with rUTIs in women with pelvic floor disorders.
  • To investigate the relationship between urogynecologic conditions and rUTIs.

Main Methods:

  • Retrospective case-control study at an academic tertiary urogynecology clinic.
  • Cases: women with rUTIs (≥2 in 6 months or ≥3 in 1 year). Controls: women with no culture-documented UTIs.
  • Matched 2:1 by age and BMI; multivariable logistic regression used for analysis.

Main Results:

  • Prolapse beyond the introitus was negatively associated with rUTIs (OR 0.28).
  • Parity (OR 1.33), Charlson Comorbidity Index (OR 1.66), and postvoid residual volume ≥100 mL (OR 4.05) were positively associated with rUTIs.

Conclusions:

  • In urogynecology patients, prolapse is protective against rUTIs, while parity, comorbidities, and urinary retention are risk factors.
  • Further research is needed to understand these associations and inform preventive measures for rUTIs.