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Updated: Jun 14, 2026

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

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Published on: March 1, 2013

Vitamin B3 Containing Polymers for Nanodelivery.

Prosper P Mapfumo^1,2, Jana I Solomun^1,2, Friedrich Becker³

¹Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany.

Macromolecular Bioscience

|March 14, 2024

Summary

This summary is machine-generated.

New vitamin B3-derived polymers create nanoparticles for drug delivery. These biocompatible nanoparticles show high drug encapsulation and boost cell metabolism, offering potential for advanced therapeutics.

Keywords:

drug delivery nanoparticles niacin polymers vitamin B

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Published on: August 11, 2018

Area of Science:

Biomaterials Science
Polymer Chemistry
Nanotechnology

Background:

Polymeric nanoparticles (NPs) offer controlled release of bioactive molecules and drugs.
Key design targets for NPs include biocompatibility, cellular uptake, and encapsulation efficiency.

Purpose of the Study:

To synthesize and characterize a polymer library derived from niacin (vitamin B3).
To evaluate the potential of these polymers in developing NPs for drug delivery and cellular enhancement.

Main Methods:

Synthesis of three niacin-derived polymers: poly(2-(acryloyloxy)ethyl nicotinate) (PAEN), poly(2-acrylamidoethyl nicotinate) (PAAEN), and poly(N-(2-acrylamidoethyl)nicotinamide) (PAAENA).
Formulation of NPs and characterization using scanning electron microscopy and dynamic light scattering.
Encapsulation studies with neutral lipid orange (NLO) and biological investigations on NP toxicity, cellular uptake, and metabolic activity.

Main Results:

Hydrophobic NPs exhibited homogeneous spherical distribution with diameters <150 nm.
Acrylamide-based polymers showed significantly higher encapsulation efficiency (96%) compared to acrylate-based polymers (46%).
P(AEN) and P(AAEN) NPs demonstrated non-toxicity, superior cellular uptake, and enhanced cell metabolic activity due to niacin release.

Conclusions:

Niacin-derived polymers can be effectively formulated into NPs for drug delivery.
The polymer backbone significantly influences encapsulation efficiency.
These nutrient-derived NPs show promise as pro-nutrient and drug-delivery materials, enhancing cellular metabolism.