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Updated: Jun 30, 2025
11:36
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
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Immune-mediated hepatitis: Basic concepts and treatment.
J A Velarde-Ruiz Velasco1, D K Tapia Calderón2, S Cerpa-Cruz3
1Servicio de Gastroenterología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Revista De Gastroenterologia De Mexico (English)
|March 14, 2024
Summary
Immune-mediated hepatitis (IMH) is an adverse event of immune checkpoint inhibitors (ICIs) cancer therapy. This review details IMH epidemiology, diagnosis, risk factors, and management, including in hepatocellular carcinoma.
Area of Science:
- Hepatology
- Oncology
- Immunology
Background:
- Immune checkpoint inhibitors (ICIs) have transformed advanced cancer treatment.
- Increased ICI use has led to more immune-mediated adverse events, particularly affecting the liver.
- Immune-mediated hepatitis (IMH) is a significant concern in patients receiving immunotherapy.
Purpose of the Study:
- To provide an updated review of immune-mediated hepatitis (IMH) in the context of cancer immunotherapy.
- To cover the epidemiology, diagnosis, risk factors, and progression of IMH.
- To discuss IMH incidence across various cancers and outline current treatment guidelines.
Main Methods:
- Literature review of recent studies on immune-mediated hepatitis.
- Analysis of epidemiological data, clinical characteristics, and risk factors.
- Synthesis of current diagnostic criteria and treatment recommendations.
Main Results:
- IMH incidence varies, presenting from mild transaminase elevations to severe hepatitis.
- Risk factors and clinical patterns of IMH are being increasingly elucidated.
- Management strategies are evolving based on clinical presentation and cancer type, including hepatocellular carcinoma.
Conclusions:
- IMH is a critical consideration in patients undergoing immunotherapy.
- Early diagnosis and appropriate management are essential to mitigate severe outcomes.
- Further research is needed to optimize treatment protocols and improve patient outcomes in IMH.
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