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Updated: Jun 30, 2025

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Neutrophil Extracellular Traps: How to Generate and Visualize Them
Published on: February 24, 2010
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Navigating the terrain of neutrophil extracellular traps in severe malaria pathogenesis
Maria Saeed1, Elizabeth H Aitken2, Stephen J Rogerson3
1Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
Trends in Parasitology
|March 14, 2024
Abstract:
Du, Ren, et al. recently showed in a Plasmodium berghei ANKA (PbA) experimental malaria model that phosphatase of regenerating liver 2 (PRL2) regulates neutrophil extracellular traps (NETs) in severe malaria (SM)-related acute lung injury (ALI). PRL2 deficiency caused SM with ALI in a mouse model by increasing NETs in pulmonary tissue; hydroxychloroquine (HCQ) may ameliorate this.

