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Updated: Jun 30, 2025
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Published on: September 12, 2011
Volumetric alterations in the basal ganglia in autism Spectrum disorder: A systematic review
Gabriel Victor Teodoro de Medeiros Marcos1, Deymisson Damitene Martins Feitosa1, Karina Maia Paiva1
1Laboratory of Experimental Neurology, Department of Health Sciences, State University of Rio Grande do Norte, Mossoró, RN, Brazil.
Introduction:
Recent research indicates that some brain structures show alterations in conditions such as Autism Spectrum Disorder (ASD). Among them, are the basal ganglia that are involved in motor, cognitive and behavioral neural circuits.
Objective:
Review the literature that describes possible volumetric alterations in the basal ganglia of individuals with ASD and the impacts that these changes have on the severity of the condition.
Methodology:
This systematic review was registered in the design and reported according to the PRISMA Items and registered in PROSPERO (CRD42023394787). The study analyzed data from published clinical, case-contemplate, and cohort trials. The following databases were consulted: PubMed, Embase, Scopus, and Cochrane Central Register of Controlled Trials, using the Medical Subject Titles (MeSH) "Autism Spectrum Disorder" and "Basal Ganglia". The last search was carried out on February 28, 2023.
Results:
Thirty-five eligible articles were collected, analyzed, and grouped according to the levels of alterations.
Conclusion:
The present study showed important volumetric alterations in the basal ganglia in ASD. However, the examined studies have methodological weaknesses that do not allow generalization and correlation with ASD manifestations.
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