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Updated: May 31, 2026

Experimental Models for Study of Retinal Pigment Epithelial Physiology and Pathophysiology
Published on: November 6, 2010
Internal limiting membrane peeling in rhegmatogenous retinal detachment: A meta-analysis
Guohai Chen1, Radouil Tzekov2, Yan Fang1
1Department of Ophthalmology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, PR China.
Internal limiting membrane (ILM) peeling during pars plana vitrectomy for rhegmatogenous retinal detachment (RRD) does not affect visual acuity or recurrence rates. However, ILM peeling significantly reduces the risk of epiretinal membrane formation.
Area of Science:
- Ophthalmology
- Retinal Surgery
- Surgical Outcomes
Background:
- Rhegmatogenous retinal detachment (RRD) is a serious condition requiring surgical intervention.
- Pars plana vitrectomy (PPV) is a common surgical approach for RRD.
- Internal limiting membrane (ILM) peeling is a technique sometimes employed during PPV.
Approach:
- A meta-analysis was performed on 14 studies involving 2259 eyes.
- Compared outcomes of PPV with and without ILM peeling for RRD.
- Analyzed best corrected visual acuity (BCVA), epiretinal membrane (ERM) formation, and RRD recurrence rates.
Key Points:
- ILM peeling did not significantly impact BCVA or RRD recurrence rates.
- ILM peeling was associated with a significantly lower rate of postoperative ERM formation (OR = 0.13).
- Sub-analysis for macula-off RRD showed similar results.
Conclusions:
- ILM peeling in PPV for RRD yields comparable functional and anatomical outcomes to non-peeling.
- ILM peeling significantly reduces the incidence of postoperative ERM.
- Consider ILM peeling in RRD cases with risk factors for ERM development.
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