Related Experiment Video
Updated: Jun 30, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Is There Utility in Preoperative Testing of Hemoglobin Before Primary Cheiloplasty?
Aryan Shay1, Megan Gaffey2, Roger Roe3
1Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR, USA.
Abstract:
ObjectiveTo examine whether a preoperative hemoglobin of less than 10 g/dL is associated with a higher rate of perioperative complications.DesignRetrospective review.SettingTertiary academic hospital at Arkansas Children's Hospital of Little Rock, Arkansas.PatientsA retrospective chart review evaluated patients undergoing primary cleft lip surgery from 2012 to 2017.InterventionsNo prospective intervention was performed for this study care.Main Outcome MeasuresAge, sex, medical history, weight, and perioperative complications. Hemoglobin level was collected in the preoperative area. The primary outcome was rate of perioperative complications including infection, dehiscence, return to the operating room, unplanned admission, and emergency department visit within two weeks postoperatively.Results105 patients undergoing primary cheiloplasty met inclusion criteria. Hemoglobin levels were obtained on all patients. 93.3% (n = 98) of patients had a hemoglobin of >10 g/dL before surgery, and 6.6% (n = 7) had levels <10 g/dL. 1 of 7 patients with a hemoglobin of <10 g/dL experienced a postoperative complication (Tet spell) and one patient with a hemoglobin of >10 g/dL experienced a postoperative complication (unplanned intensive care admission for respiratory distress).ConclusionsPost-operative complications are rare after primary cheiloplasty in patients with low or normal hemoglobin levels. The results of this study show that a preoperative hemoglobin of <10 g/dL does not predict perioperative complications in patients undergoing primary cheiloplasty.

