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Prochirality

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...

Chirality

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...

Chirality in Nature

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.

Properties of Enantiomers and Optical Activity

Properties of Enantiomers and Optical Activity

It is essential to understand the difference between chiral and achiral interactions and the implications thereof in optical activity and their applications. Just as our feet, which are chiral, interact uniquely with chiral objects, such as a pair of shoes, but identically with achiral socks, enantiomers of a molecule exhibit different properties only when they interact with other chiral media. An example of a significant implication from this facet is the phenomenon known as optical activity,...

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...

Molecules with Multiple Chiral Centers

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...

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Related Experiment Video

Updated: Jun 30, 2025

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

Inverse chirality-induced spin selectivity effect in chiral assemblies of π-conjugated polymers.

Rui Sun¹, Kyung Sun Park², Andrew H Comstock¹

¹Department of Physics and Organic and Carbon Electronics Lab (ORaCEL), North Carolina State University, Raleigh, NC, USA.

Nature Materials

|March 16, 2024

Summary

Researchers observed the inverse chirality-induced spin selectivity effect in chiral polymers, enabling spin-to-charge conversion measurements. This opens new avenues for printable spintronic devices operating at room temperature.

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A Micropatterning Assay for Measuring Cell Chirality

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Last Updated: Jun 30, 2025

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

A Micropatterning Assay for Measuring Cell Chirality

A Micropatterning Assay for Measuring Cell Chirality

Published on: March 11, 2022

Area of Science:

Condensed Matter Physics
Materials Science
Organic Electronics

Background:

Chirality-induced spin selectivity (CISS) couples spin and charge currents in chiral materials for spintronics.
The reciprocal effect, inverse CISS, was previously unexplored in chiral systems.

Purpose of the Study:

To observe and characterize the inverse CISS effect in chiral π-conjugated polymer assemblies.
To quantify longitudinal spin-to-charge conversion driven by CISS in polymers.
To explore spintronic applications using printable chiral materials.

Main Methods:

Utilized spin-pumping techniques to probe the inverse CISS effect.
Employed a printing method to tune polymer conductivity and supramolecular chirality.
Measured spin relaxation times parallel to the chiral axis.

Main Results:

Successfully observed the inverse CISS effect in chiral polymer assemblies.
Quantified spin-to-charge conversion efficiency across various chiral polymers.
Discovered exceptionally long spin relaxation times (up to several nanoseconds) along the chiral axis.

Conclusions:

The inverse CISS effect provides a tool to study spin-chirality interactions.
Printable chiral polymer assemblies exhibit promising properties for spintronics.
This work paves the way for novel room-temperature spintronic devices.