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Area of Science:

  • Biomedical Engineering
  • Developmental Biology
  • Oncology

Background:

  • Organoid and spheroid technologies are crucial for studying developmental biology and oncology.
  • Optical coherence tomography (OCT) is a label-free imaging method for biological samples.
  • Opaqueness of mature organoids limits OCT penetration, necessitating multi-angle imaging approaches.

Purpose of the Study:

  • To develop a non-contact, multi-angle imaging method for opaque biological samples.
  • To enable controlled reorientation of organoids and spheroids for enhanced OCT analysis.
  • To improve volumetric imaging capabilities for developmental biology and oncology research.

Main Methods:

  • Development of an ultrasound-induced reorientation system using a 3D-printed acoustic trap.
  • Integration of the acoustic trap into an OCT imaging setup for sample levitation and manipulation.
  • Application of a model-based algorithm for fusion of multi-angle OCT data from unknown angles.

Main Results:

  • Demonstrated controlled levitation and reorientation of zebrafish larvae and tumor spheroids.
  • Achieved enhanced penetration depth through joint 3D-recovery of reflectivity, attenuation, and refractive index.
  • Successfully registered positions of zebrafish larvae in 3D space.

Conclusions:

  • The ultrasound-induced reorientation method provides a powerful tool for multi-angle OCT imaging of challenging biological samples.
  • This technique overcomes limitations of OCT in imaging opaque organoids and spheroids.
  • Enables advanced volumetric imaging for future applications in developmental biology and oncology.