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Coenzyme Q10 in atherosclerosis

Minjun Liao1, Xueke He2, Yangyang Zhou1

  • 1Institute of Cardiovascular Disease, Department of Pathophysiology, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, 421001, PR China; Department of Clinical Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, PR China.

European Journal of Pharmacology
|March 17, 2024
PubMed

Insights

Coenzyme Q10 (CoQ10) demonstrates protective effects against atherosclerosis, a major cause of cardiovascular death. Research indicates CoQ10 may mitigate key disease processes, suggesting its therapeutic potential.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Nutritional Science

Background:

  • Atherosclerosis is a leading cause of global cardiovascular mortality, particularly in the elderly.
  • Key pathological processes include abnormal lipid metabolism, endothelial dysfunction, inflammation, and oxidative stress.
  • Coenzyme Q10 (CoQ10) is an essential mitochondrial component and potent antioxidant.

Purpose of the Study:

  • To review the role of CoQ10 in the electron transport chain and its antioxidant functions.
  • To explore CoQ10's physiological impact on oxidative stress, inflammation, lipid metabolism, and autophagy.
  • To assess CoQ10's therapeutic potential in mitigating atherosclerosis progression.

Main Methods:

  • Literature review of CoQ10's forms in the electron transport chain.
  • Analysis of CoQ10's physiological regulatory roles.
  • Examination of molecular mechanisms, animal models, and clinical evidence of CoQ10 in atherosclerosis.

Main Results:

  • CoQ10 mitigates lipid transport abnormalities, endothelial inflammation, metabolic disturbances, and thrombotic processes in atherosclerosis.
  • Evidence from molecular, animal, and clinical studies supports CoQ10's beneficial effects.
  • Combined CoQ10 therapy shows synergistic effects with other drugs.

Conclusions:

  • CoQ10 exhibits significant potential as a therapeutic agent for atherosclerotic cardiovascular diseases.
  • Further basic and clinical research is warranted to fully establish CoQ10's role in treatment.
  • CoQ10 may offer a novel strategy to combat cardiovascular mortality associated with atherosclerosis.

Keywords:
AtherosclerosisCoenzyme Q10InflammationLipid metabolismOxidative stress

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