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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

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Updated: Jun 30, 2025

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

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MSCs-Derived Decellularised Matrix: Cellular Responses and Regenerative Dentistry.

Suphalak Phothichailert¹, Shirel Samoun², Benjamin P Fournier³

¹Center of Excellence for Dental Stem Cell Biology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

International Dental Journal

|March 17, 2024

Summary

Mesenchymal stem cell-derived decellularized extracellular matrix (dECM) enhances cell adhesion, proliferation, and differentiation. Dental MSC-derived dECM shows significant promise for regenerative dentistry applications.

Keywords:

Cell differentiation Cell proliferation Decellularisation Extracellular matrix Mesenchymal stem cell Regenerative dentistry

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Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

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Published on: January 7, 2019

Area of Science:

Biomaterials Science
Regenerative Medicine
Cell Biology

Background:

Decellularized extracellular matrix (dECM) is a naturally derived biomaterial crucial for cell signaling.
ECM composition varies with culture conditions, influencing cell survival and differentiation.
Cell-derived ECM provides a 3D structure impacting cell behavior.

Purpose of the Study:

To review the effects of dECM derived from mesenchymal stem cells (MSCs) on in vitro cell responses.
To evaluate MSC-derived dECM's potential in tissue engineering and regenerative medicine.

Main Methods:

Systematic literature search of PubMed (2005-2022) using keywords: MSCs, decellularization, cell culture.
Review of 41 articles based on specific criteria for ECM origin, decellularization, and production methods.
Analysis of dECM effects on cell migration, proliferation, and differentiation.

Main Results:

MSCs-derived dECM supports cell adhesion and enhances cell proliferation.
MSCs-derived dECM promotes cell differentiation.
dECM from dental MSCs demonstrates potential in regenerative dentistry.

Conclusions:

Cell-based dECMs are a promising biomaterial for tissue engineering.
MSC-derived dECM offers a viable option for innovative regenerative medicine approaches.
Further research into dental MSC-derived dECM is warranted for clinical applications.