Prognostic value of tumor‑associated CD177⁺ neutrophils in lung adenocarcinoma

The aim of the present study was to detect CD177⁺ neutrophils in tumor tissues and analyze their association with the clinical characteristics and prognosis of patients with lung adenocarcinoma (LUAD). Immunohistochemistry was used to detect CD177⁺ neutrophils in tumors and adjacent tissues of 16 patients with LUAD who underwent curative surgical resection. A total of 120 patients with LUAD were recruited, and their clinical data were collected; survival follow-up was performed. CD177⁺ neutrophils in tumor tissues were detected via immunohistochemistry, and the association between CD177⁺ neutrophils and clinical characteristics was analyzed. The density of CD177⁺ neutrophils in tumor tissues and adjacent tissues of patients with LUAD was analyzed using t-test, and the association between CD177⁺ neutrophils and clinical characteristics was analyzed through the Chi-square test. Survival was calculated using the Kaplan-Meier survival rate curve. Finally, the association between these indicators and the survival of LUAD patients was evaluated using Cox regression analysis. CD177⁺ neutrophil infiltration was significantly higher in LUAD tumor tissues, and the high density of CD177⁺ neutrophils was associated with the clinical characteristics of TNM stage, tumor differentiation and poor progression-free and overall survival in LUAD. In conclusion, tumor-associated CD177⁺ neutrophils associated with malignant progression and poor prognosis may be independent and unfavorable prognostic biomarkers for LUAD.