Related Experiment Video
Updated: Jun 30, 2025
06:04
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
871
Association of pulse pressure and aortic root diameter in elderly Chinese patients with chronic heart failure
Lu Chen1, Wenhui Xie1, Xuhui Hong1
1Department of Geriatrics, Fujian Key Laboratory of Vascular Aging, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Frontiers in Cardiovascular Medicine
|March 18, 2024
Summary
Pulse pressure (PP) is linked to aortic root diameter (AoD) in elderly heart failure with reduced ejection fraction (HFrEF) patients, suggesting vascular aging contributes to aortic dilation in this group.
Area of Science:
- Cardiology
- Vascular Biology
- Geriatrics
Background:
- High pulse pressure (PP) and aortic root diameter (AoD) are indicators of vascular aging and risk factors for cardiovascular disease, including heart failure (HF).
- The specific relationship between PP and AoD in HF patients remains unclear.
- This study investigated the association between PP and AoD in middle-aged and elderly individuals with HF.
Purpose of the Study:
- To evaluate the relationship between pulse pressure and aortic root diameter in middle-aged and elderly patients with heart failure.
- To identify factors associated with aortic root diameter in heart failure patients.
- To determine the risk of aortic root dilation based on pulse pressure levels.
Main Methods:
- A total of 1,027 Chinese patients with heart failure (HFrEF, HFmrEF, HFpEF) were analyzed.
- Pearson correlation, multiple linear regression, and multivariate logistic regression were employed.
- The findings were validated in an independent cohort of 378 HFrEF patients.
Main Results:
- A positive correlation was found between PP and AoD in middle-aged and elderly HFrEF patients.
- PP, age, and BMI were independently associated with AoD in HFrEF.
- Increased aortic root dilation risk was observed in the highest PP quartile, particularly in patients aged 65 and older.
Conclusions:
- Pulse pressure is independently and positively associated with aortic root diameter, especially in elderly HFrEF patients.
- This association was not significant in HFmrEF or HFpEF patients.
- Arterial stiffening and vascular aging likely contribute to aortic dilation in elderly HFrEF patients.
Related Concept Videos
01:24Blood Pressure
3.0K
The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
3.0K
01:21Sites for measruring blood pressure
1.7K
Blood pressure measurement is a fundamental clinical procedure, providing crucial data for assessing cardiovascular health. Among the various sites for this measurement, the brachial and popliteal arteries are predominantly utilized due to their accessibility and the reliability of their readings. This lesson delves into the anatomical significance, methodology, and considerations of measuring blood pressure at these locations.
The Brachial Artery: Primary Site for Blood Pressure Measurement
The Brachial Artery: Primary Site for Blood Pressure Measurement
1.7K
01:16Pulse
510
When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical...
The pulse serves as a clinical...
510
01:17Measurement of Blood Pressure
924
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
924
01:13Special considerations while measuring pulse
578
Assessing a patient's pulse is a fundamental skill in healthcare, but certain situations require special attention:
578
01:28Special considerations while measuring blood pressure
722
When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
722