Related Experiment Video

Updated: Jun 30, 2025

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

871

Beyond acute infection: molecular mechanisms underpinning cardiovascular complications in long COVID

Roba Hamed Mostafa1,2, Ahmed Moustafa1,2,3

  • 1Systems Genomics Laboratory, American University in Cairo, New Cairo, Egypt.

Frontiers in Cardiovascular Medicine
|March 18, 2024
PubMed

Insights

Long COVID, a persistent condition after SARS-CoV-2 infection, causes lasting cardiovascular issues even in asymptomatic cases. This review explores these complications, treatments, and potential transgenerational effects.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • SARS-CoV-2 infection leads to significant cardiovascular complications, impacting patients long after acute illness.
  • These persistent cardiovascular issues, part of post-acute COVID-19 syndrome (PACS) or Long COVID, affect both symptomatic and asymptomatic individuals.
  • With over 756 million global cases, Long COVID presents substantial health and healthcare system challenges.

Purpose of the Study:

  • To comprehensively review the persistent cardiovascular complications associated with COVID-19.
  • To explore emerging therapeutic strategies for managing these cardiovascular sequelae.
  • To discuss potential transgenerational repercussions of SARS-CoV-2 infection.

Main Methods:

  • Systematic literature review of studies on cardiovascular complications of COVID-19.
  • Analysis of data on the prevalence and nature of Long COVID cardiovascular manifestations.
  • Evaluation of current and emerging treatment options for cardiovascular sequelae.

Main Results:

  • COVID-19 frequently results in prolonged cardiovascular issues, including myocarditis, arrhythmias, and thromboembolic events.
  • Long COVID cardiovascular complications affect a wide range of cardiac functions and structures.
  • Emerging therapies show promise in mitigating symptoms and improving outcomes, though further research is needed.

Conclusions:

  • Persistent cardiovascular complications are a major concern of Long COVID, necessitating ongoing clinical attention.
  • Therapeutic strategies are evolving to manage these sequelae, requiring further investigation and validation.
  • The potential for transgenerational effects of SARS-CoV-2 on cardiovascular health warrants urgent research and proactive measures.

Keywords:
SARS-CoV-2cardiovascularlong COVIDpost-acute COVID-19 syndrome (PACS)transgenerational inheritance

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.2K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.0K

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
30
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.8K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.8K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
81