Normative modeling of thalamic nuclear volumes
Taylor Young1,2, Vinod Jangid Kumar3, Manojkumar Saranathan4
1Department of Psychiatry, University of Massachusetts Chan Medical School, Worcester, MA.
Medrxiv : the Preprint Server for Health Sciences
|March 18, 2024
Summary
This study introduces the first normative models for thalamic nuclear volumes, revealing significant atrophy patterns in neurodegenerative and psychiatric disorders like Alzheimer's disease and schizophrenia.
Area of Science:
- Neuroimaging
- Neuroanatomy
- Computational Neuroscience
Background:
- Thalamic nuclei are crucial in cognitive and psychiatric disorders, yet normative volume models are lacking.
- Understanding thalamic volume changes is key to diagnosing and treating these conditions.
Approach:
- Developed novel HIPS-THOMAS segmentation for thalamic nuclei from T1 MRI data.
- Established normative models using GAMLSS, controlling for sex, intracranial volume, and site.
- Analyzed thalamic nuclear volumes in 2374 healthy controls and 695 patients with cognitive and psychiatric disorders.
Key Points:
- Significant atrophy observed in most neurodegenerative and psychiatric phenotypes.
- Progressive bilateral atrophy from early mild cognitive impairment to Alzheimer's disease, with left-sided predilection.
- Heterogeneous thalamic changes in psychiatric disorders, notably right-sided predilection.
Conclusions:
- Presents the first normative models for thalamic nuclear volumes.
- Demonstrates the utility of these models in identifying distinct atrophy patterns across diverse neurological and psychiatric conditions.
- Highlights potential for improved diagnostic and prognostic tools for thalamic dysfunction.
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