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Updated: Jun 30, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Au-allenylidene promoted decarboxylative annulation to access unsaturated γ-lactams/lactones
Xuelun Duan1, Haotian Shi1, Yangyang Yue1
1Central Hospital of Dalian University of Technology, School of Chemistry, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, P. R. China. wzsong@dlut.edu.cn.
Abstract:
A novel Au-allenylidene promoted decarboxylative annulation by intramolecular α-nucleophilic addition has been disclosed. The unsaturated cyclic ethynylethylene carbamates/carbonates can be converted to unique nucleophiles attached with alkylidene ketenes by sequential decarboxylation and oxidation processes. Such alkylidene ketenes can be rapidly trapped by intramolecular α-attacking annulation to generate potential biological active unsaturated γ-lactams/lactones with broad scope, facile post-modification, high regioselectivity and efficiency.
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