Related Experiment Video

Updated: Jun 30, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

409

The role of PI3K/Akt signaling pathway in chronic kidney disease

Hongshuang Wang1, Lanjun Gao1, Chenchen Zhao1

  • 1Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China.

International Urology and Nephrology
|March 18, 2024
PubMed

Insights

Targeting the phosphatidylinositol 3-kinases (PI3K)/protein kinase B (Akt) pathway shows promise for treating chronic kidney disease (CKD). Modulating this pathway may reduce kidney damage by impacting inflammation, apoptosis, and autophagy.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Pharmacology

Background:

  • Chronic kidney disease (CKD) encompasses conditions like glomerulonephritis, IgA nephropathy, and diabetic nephropathy, marked by kidney structural damage and functional decline.
  • Current CKD treatments focus on symptom management, lacking disease-modifying therapies.
  • The phosphatidylinositol 3-kinases (PI3K)/protein kinase B (Akt) signaling pathway is implicated in CKD pathogenesis.

Purpose of the Study:

  • To review the role of the PI3K/Akt pathway in CKD-related inflammation, apoptosis, autophagy, and epithelial-mesenchymal transition (EMT).
  • To summarize current evidence on targeting the PI3K/Akt pathway for CKD treatment.
  • To identify research gaps and challenges in developing PI3K/Akt-targeted CKD therapies.

Main Methods:

  • Literature review of studies investigating the PI3K/Akt pathway in CKD.
  • Analysis of preclinical and clinical data on PI3K/Akt modulators in CKD models.
  • Synthesis of information on the pathway's involvement in key pathological processes.

Main Results:

  • The PI3K/Akt pathway significantly influences inflammation, oxidative stress, apoptosis, autophagy, and EMT in CKD.
  • Inhibiting or activating specific components of the PI3K/Akt pathway can ameliorate kidney damage.
  • Emerging therapeutic strategies focus on modulating this pathway for CKD treatment.

Conclusions:

  • The PI3K/Akt pathway is a critical regulator of CKD progression and a potential therapeutic target.
  • Further research is needed to overcome challenges in translating PI3K/Akt-targeted therapies into clinical practice for CKD.
  • Developing effective CKD treatments requires a deeper understanding of PI3K/Akt pathway modulation.

Keywords:
Chronic kidney diseaseMechanismPI3K/AktTherapeutic target

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