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Targeting NAD+ Metabolism to Modulate Autoimmunity and Inflammation
Jing Wu1, Kim Han1, Michael N Sack1
1Laboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Journal of Immunology (Baltimore, Md. : 1950)
|March 18, 2024
Summary
Nicotinamide adenine dinucleotide (NAD+) is crucial for cellular health, but declines with age and disease. Boosting NAD+ levels may improve healthspan in inflammatory and autoimmune conditions.
Area of Science:
- Immunology and Cellular Metabolism
- Focuses on the role of NAD+ in immune regulation and inflammation.
Background:
- Nicotinamide adenine dinucleotide (NAD+) is vital for redox balance and enzymatic functions.
- NAD+ levels decrease with aging and are depleted in inflammatory and autoimmune diseases.
- Aberrant immune activation consumes NAD+, impacting cellular health.
Approach:
- Reviews NAD+ biology and its regulatory roles in immunity and inflammation.
- Examines NAD+ augmentation strategies via salvage and Priess-Handler pathways.
- Discusses emerging studies on NAD+ boosting in animal models and human diseases.
Key Points:
- NAD+ serves as a coenzyme and cofactor, essential for numerous cellular processes.
- Declining NAD+ levels are implicated in aging and immune-related pathologies.
- NAD+ boosting is explored as a therapeutic strategy for inflammation-linked diseases.
Conclusions:
- NAD+ plays a pivotal role in regulating immune responses and inflammation.
- NAD+ augmentation presents a promising avenue for improving healthspan in disease.
- Further research is needed to fully elucidate the mechanisms of NAD+ boosting therapies.
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